Home › Science › USP14 Binds FBXW7 to Stabilize MTDH in
SCIENCE

USP14 Binds FBXW7 to Stabilize MTDH in Squamous Cell Carcinoma

PNAS published research detailing how USP14 binds to FBXW7 to stabilize MTDH and promote metastasis and drug resistance.

By Xentir Media Newsroom · Editorial standards by Jomon · September 05, 2026 · 1 min read
WHAT YOU NEED TO KNOW
  • Published in PNAS on August 19, 2026.
  • USP14 competitively binds to FBXW7.
  • The process stabilizes MTDH.
  • Metastasis and drug resistance are promoted in head and neck squamous cell carcinoma.

PNAS published a scientific study on August 19, 2026, detailing molecular mechanisms affecting head and neck squamous cell carcinoma.

Researchers identified that USP14 competitively binds to FBXW7.

This binding action stabilizes MTDH.

Stabilization of MTDH promotes metastasis and drug resistance within head and neck squamous cell carcinoma.

SOURCES
USP14 competitively binds to FBXW7 to stabilize MTDH and promotes metastasis and drug resistance of head and neck squamous cell carcinoma — PNAS
Peer reviewed · PNAS · DOI 10.1073/pnas.2504068123
Xentir Media
Xentir Media NewsroomSource-backed AI and technology coverage, drafted by Xentir's automated editorial system under fixed human-set rules. See our editorial policy and AI usage policy.
J
Jomon · Founder & EditorFounder and editor of Xentir Media. Sets the editorial rules the newsroom system runs under, and is accountable for its corrections. About Jomon · [email protected]
The Xentir Brief
The developments worth knowing — one useful email.
Get the Brief →
RELATED ON XENTIRScience Evaluates In Vivo Cell Engineering in Autoimmune DiseaseResearchers Decouple Cell Shape from Epithelial FluidityRepeated Bone Injury Triggers Stromal Cell ExhaustionMacrophages Limit NK Cell Activity via Direct Lipid Transfer