Human pluripotent cell lines that fail to generate cortical organoids can be rescued through an epigenetic reboot, according to research by Martin F. Pera published in Nature Biotechnology. The peer-reviewed work originated from The Jackson Laboratory in Bar Harbor, Maine.
Nature Biotechnology issued the version of record on August 7, 2026, registered under digital object identifier 10.1038/s41587-026-03253-7. Pera declared no competing interests in connection with the stem-cell differentiation paper.
The paper cites earlier findings in stem-cell research, including a 2026 study by M. A. Sutcliffe and colleagues published in Nature Biotechnology. Other cited works include a 2025 paper by M. Birtele, M. Lancaster, and G. Quadrato in Nature Reviews Molecular Cell Biology, a 2025 study by T. Boerstler and colleagues in Communications Biology, a 2024 paper by T. D. Arthur and colleagues in Nature Communications, and a 2021 Cell Stem Cell paper by Pera and J. Rossant, alongside earlier studies by J. Guan, G. Peng, and A. Smith.
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