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Bacterial Couriers Deliver Drugs Into Cancers

Nature reports on innovative therapies using genetically engineered bacteria to deliver molecules directly to tumours.

WHAT YOU NEED TO KNOW
  • John Heller was diagnosed with advanced pancreatic cancer in the summer of 2023.
  • Daniel Saltzman developed a therapy using genetically engineered Salmonella Typhimurium bacteria.
  • The therapy delivers interleukin-2, an immune-system-activating molecule, to tumours.

Nature reported on an innovative therapy developed by surgeon Daniel Saltzman at the University of Minnesota in Minneapolis.

Patient John Heller was diagnosed with advanced pancreatic cancer in the summer of 2023 and began chemotherapy with an expected survival of about a year.

Saltzman developed a therapy using genetically engineered Salmonella Typhimurium bacteria to deliver interleukin-2, a potent immune-system-activating molecule, directly to tumours.

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